Structure of PDB 8pyi Chain FFF

Receptor sequence
>8pyiFFF (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
YVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN
EAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGD
LKSYLRSLRPPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE
DFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSDVWSF
GVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMC
WQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEEN
3D structure
PDB8pyi Human IGF1R with inhibitor 6
ChainFFF
Resolution3.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IER FFF L1005 G1006 F1010 V1013 A1031 K1033 F1047 M1054 V1063 M1079 M1082 M1142 I1151 G1152 D1153 L19 G20 F24 V27 A45 K47 F61 M68 V77 M93 M96 M147 I156 G157 D158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8pyi, PDBe:8pyi, PDBj:8pyi
PDBsum8pyi
PubMed
UniProtP08069|IGF1R_HUMAN Insulin-like growth factor 1 receptor (Gene Name=IGF1R)

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