Structure of PDB 7q5w Chain FFF

Receptor sequence
>7q5wFFF (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
DSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAH
GRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPF
NRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKL
IATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCL
LHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTV
PCQKI
3D structure
PDB7q5w The tandem SH2 domains of SYK
ChainFFF
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide FFF R22 R42 H63 Y64 T65 A77 G98 L99 R175 R195 R197 H215 Y216 R217 I228 E230 G231 K232 K247 D249 G250 L251 R15 R35 H56 Y57 T58 A70 G91 L92 R168 R188 R190 H208 Y209 R210 I221 E223 G224 K225 K240 D242 G243 L244
BS02 peptide FFF K222 P229 K215 P222
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity

View graph for
Molecular Function
External links
PDB RCSB:7q5w, PDBe:7q5w, PDBj:7q5w
PDBsum7q5w
PubMed
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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