Structure of PDB 6sg9 Chain FF

Receptor sequence

>6sg9FF (length=408) Species: 5702 (Trypanosoma brucei brucei)

MKRIVVPHRWSEMNRVEHPPLMMKQLFQGVCGGLRWLETKSLAQYLAVRA
IEEGYPSTPGVRSLQVTKQKRLVSYDVLDCTLGSGYHAGAVLENGGPYTR
VVALDCDHDAMHAARDLVEEFGGDRFRFYCCKMSEAKAMFGERSFDAIMI
DGGVSDTQLEDPERGFLLDDEGGHRLDMRFGPQMGVGALEYLNTVSQHTL
VSSLLAYGLLEYGQAMKMSRAITRRKPFVDSREVLTCIEQAGDELPEGGW
RSQGSRRKSPMSWKFLTSLRCIINNEMYELRQGIENALLMLRDDGRLVVF
SRLPWEERLVRGTVDDHPHALLSYVEDISIDDVQIYGFTRHAKMWVITRA
ASSAYALKNTTTLTEEKFRESSVRWLTGMYAGQTHGFPANNFTFENFERK
EWVTLRRN

3D structure

• PDB: 6sg9 Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.
• Chain: FF
• Resolution: 3.1 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	FF	Q250 H251	Q197 H198
BS02	rna	FF	Y433 A434 G435 T437 H438 T446 F447 N449 E451 R452 K453	Y380 A381 G382 T384 H385 T393 F394 N396 E398 R399 K400
BS03	peptide	FF	A43 Q44 A47 P150	A43 Q44 A47 P97
BS04	SAH	FF	H18 T134 L135 G136 H140 D158 C159 M186 D204 S208 Q211 F233 E332	H18 T81 L82 G83 H87 D105 C106 M133 D151 S155 Q158 F180 E279

Gene Ontology

Molecular Function

• GO:0008168 methyltransferase activity
• GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity

Biological Process

• GO:0032259 methylation
• GO:0070475 rRNA base methylation

Cellular Component

• GO:0005739 mitochondrion

External links

• PDB: RCSB:6sg9, PDBe:6sg9, PDBj:6sg9
• PDBsum: 6sg9
• PubMed: 31515389
• UniProt: Q57W60