Structure of PDB 6z0u Chain FA

Receptor sequence
>6z0uFA (length=454) Species: 371094 (Chikungunya virus strain S27-African prototype) [Search protein sequence]
PVYVDIDADSAFLKALQRAYPMFEVEPRQVTPNDHANARAFSHLAIKLIE
QEIDPDSTILDIGSAPARRMMSDRKYHCVCPMRSAEDPERLANYARKLAS
AAGKVLDRNISGKIGDLQAVMAVPDTETPTFCLHTDVSCRQRADVAIYQD
VYAVHAPTSLYHQAIKGVRLAYWVGFDTTPFMYNAMAGAYPSYSTNWADE
QVLKAKNIGLCSTDLTEGRRGKLSIMRGKKLEPCDRVLFSVGSTLYPESR
KLLKSWHLPSVFHLKGKLSFTCRCDTVVSCEGYVVKRITMSPGLYGKTTG
YAVTHHADGFLMCKTTDTVDGERVSFSVCTYVPATICDQMTGILATEVTP
EDAQKLLVGLNQRNTNTMKNYMIPVVAQAFSKWAKECRKDMEDEKLLGVR
ERTLTCCCLWAFKKQKTHTVYKRPDTQSIQKVQAEFDSFSGLSIPLRTRI
KWLL
3D structure
PDB6z0u Capping pores of alphavirus nsP1 gate membranous viral replication factories.
ChainFA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN FA H79 E129 C134 H77 E127 C132
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008174 mRNA methyltransferase activity
Biological Process
GO:0006396 RNA processing
GO:0016556 mRNA modification

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Molecular Function
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Biological Process
External links
PDB RCSB:6z0u, PDBe:6z0u, PDBj:6z0u
PDBsum6z0u
PubMed33328629
UniProtQ8JUX6|POLN_CHIKS Polyprotein P1234

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