Structure of PDB 6sgb Chain FA

Receptor sequence

>6sgbFA (length=579) Species: 5702 (Trypanosoma brucei brucei)

GYTFADFLRRLERSPDSHMAPLYHEHRELFVRRHDMFARVISSVTWSKGV
ALVAAAGYTQAVNVTIYRALLARMLLHNRHVRQCGAGSVVPWSAALRTYS
EAIATHGNAVPTRMTLSALRLCTPARQWVAAISLLMLSQANDKLTLPMLI
DAAGCCATPAAWEKAMALLGRFHAQSLQVLPDSIQSLRPVGTSASTVDAA
AHALLPRSEGPTPEQKHILTVINKVVSAVPWQVALSNEMCRSYLTHLVAS
TTLRPTEKTASLTTAVQQLPWEAFVTLMKTVTATVQEGSQSNSIIREGVN
LLQSEPETAIPFITTILYKLPSAEAAALFLSEATSAYRNSSSAVVAAAIR
HPVVVGALLKRCADSNSWYLAASIFKSTSPTAIPCDVASDLVIQMRRANQ
APLVVDVLQKYIVPSRTKLTEEAIEAALLCVLVHNRALAKASGVHWISAL
SWATDLLEEGVESRILQTGTTPSVGGVNHEDPTVLLRKKTLSPRILSLLI
YICVNAGSPRGGLFALGYARTVSKTELELSEEITALLYCMMYDRPREAES
IIQHAVKKHGEYKGKYLGRLLVASQEAKG

3D structure

• PDB: 6sgb Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.
• Chain: FA
• Resolution: 3.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	FA	P165 W168 M172 H179 L183 I190 Q191 R194 W237 N243 E244 M245 S248 T251 H252 P276 E278 G294	P159 W162 M166 H173 L177 I184 Q185 R188 W231 N237 E238 M239 S242 T245 H246 P270 E272 G288
BS02	peptide	FA	W98 S99 L102 S106 Q133 W134 K170	W92 S93 L96 S100 Q127 W128 K164

Gene Ontology

Cellular Component

• GO:0005739 mitochondrion
• GO:0020023 kinetoplast

External links

• PDB: RCSB:6sgb, PDBe:6sgb, PDBj:6sgb
• PDBsum: 6sgb
• PubMed: 31515389
• UniProt: Q386U1