Structure of PDB 6sgb Chain F1

Receptor sequence

>6sgbF1 (length=889) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]

LEGAMHKPGESGLQAGSSTTIAGKETWSQFSTKMRYGRRRIRVIDVAAKM
SYEYQMLRKMCKRRPAMRQWAVRDDFCDMNPGVVIMSPSMQAAFMKVFRM
KEKGLIRQCLRDIVPVIEYRNREEPARLKRSQAKLRFRIRQRLLKFQRQL
AVANAIASRSVLYSTNDAIGYFLFRGAAMYAGMHRVFFELSKQLPHFVPK
TMLDFGAGTGTAILVAKEVYDPGSLAYPLYRSLRQTMQGNDSSRTHQLSE
LRYDLKRLQRNNEEKKKVRFMAVAALLERGEVDPADLPEDLKREIAEVAT
AAATAKKDRLVREAHARYRDVVDGTEWESGDPLGEVRASTEDPEDVIDGE
QGDGGDDGEAAKGRPKTWWEKLIDVENETARTRAARRLRPLQEVTAVEPS
PGMMEIGTMVLHDDVPNVTWKRYLLPEDEAIQHDLVVAAYSLSEIATSEN
RRRIVQQLWKMTKGVLVFVEFANLNNFNILMEARDWILEEKDVGLWDWQP
TIVAPCPHEHRCPLRHCKTGVKRKRMRICSTEAHYRSTFVEVWARHMPLK
VGIEPISYLILARNELVPERAERRREQLKKAEEMKRRERDVKQQQLHEAS
LAVKDVVFERLSDEALHRVQSSVPQPLTDIDSATSTSLLKDLKDGATSTG
EIGHMPTDVPRLVKTGNTRHNRLIFPLQFPPATHKFNRAFVDAGYQRQRA
ITPAEMLVVRQEVEQLQQRVMRAAPKYLRVVRDPRCHGKVQADFCTPEGD
LVSGRVYRRFYGDRNRVSAHSTMRWQHIGGWKLLKRIRRGSLFPHNVPLY
AVTKHAQIDFPNTLLDTKHSTVEQTAMQYNDPMEISEQQWADAVRRAKIR
TVQHTKNALPFAAKKRAAQRALQVRRRNVRLEMSGNRRR

3D structure

PDB

6sgb Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.

Chain

Resolution

3.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	F1	D157 R225 L229 Q232 R233 L235 A236 V237 N239 S245 L247	D112 R140 L144 Q147 R148 L150 A151 V152 N154 S160 L162
BS02	rna	F1	P53 S56 G57 L58 M79 R83 R215 A218 K219 R221 F222 R225 Q226 R233 T604 R608 R610 V627 H631 P633 R761 Y787 Q788 R827 G830 K831 Q833 R847 Y849 R850 R851 Y853 K877 Q920 I1001 R1002 Q1005 K1016 K1017 R1018 Q1021 R1022 Q1025 R1027 R1029 N1030 R1032 L1033 E1034	P8 S11 G12 L13 M34 R38 R130 A133 K134 R136 F137 R140 Q141 R148 T519 R523 R525 V542 H546 P548 R669 Y695 Q696 R735 G738 K739 Q741 R755 Y757 R758 R759 Y761 K785 Q828 I849 R850 Q853 K864 K865 R866 Q869 R870 Q873 R875 R877 N878 R880 L881 E882
BS03	SAH	F1	Y256 M264 F290 G291 G293 T294 T296 E483 P484 M488 A524 Y525 E529 I530	Y171 M179 F205 G206 G208 T209 T211 E398 P399 M403 A439 Y440 E444 I445

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0008168	methyltransferase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005739	mitochondrion
GO:0005763	mitochondrial small ribosomal subunit

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6sgb, PDBe:6sgb, PDBj:6sgb
PDBsum	6sgb
PubMed	31515389
UniProt	Q385R2

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