Structure of PDB 9eqj Chain F

Receptor sequence
>9eqjF (length=145) Species: 9606 (Homo sapiens) [Search protein sequence]
PVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIH
SYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKE
RCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQER
3D structure
PDB9eqj Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity.
ChainF
Resolution2.05 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1H6O F P86 W88 Y98 P99 I109 H110 S111 Y112 H115 W117 P26 W28 Y38 P39 I49 H50 S51 Y52 H55 W57
External links
PDB RCSB:9eqj, PDBe:9eqj, PDBj:9eqj
PDBsum9eqj
PubMed38942127
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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