Structure of PDB 9ema Chain F

Receptor sequence
>9emaF (length=332) Species: 9606 (Homo sapiens) [Search protein sequence]
VTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVLEMIRE
GKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSK
TEALTQAFRRSIGVRIKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIK
SEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESD
MAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTTPYSEKDTKQ
ILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGT
EVQVDDIKRVYSLFLDESRSTQYMKEYQDAFL
3D structure
PDB9ema Mechanism of allosteric inhibition of RUVBL1-RUVBL2 by the small-molecule CB-6644
ChainF
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1H5V F A87 M88 A91 F100 A102 A72 M73 A76 F85 A87
BS02 ATP F A24 H25 H27 V47 P79 G80 T81 G82 K83 T84 A85 N329 Y362 R400 A9 H10 H12 V32 P64 G65 T66 G67 K68 T69 A70 N210 Y243 R281
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:9ema, PDBe:9ema, PDBj:9ema
PDBsum9ema
PubMed
UniProtQ9Y230|RUVB2_HUMAN RuvB-like 2 (Gene Name=RUVBL2)

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