Structure of PDB 8ysx Chain F

Receptor sequence
>8ysxF (length=198) Species: 9615 (Canis lupus familiaris) [Search protein sequence]
TIMAVEFDGGVVVGSDSRVSAGEAVVNRAFNKLSPLHQHIYCALSGSAAD
AQAMADMAAYQLELHGLELEEPPLVLAAANVVRNISYKYREDLSAHLMIA
GWDRRDGGQVYGTMGGMLTRQPFAIGGSGSTYIYGYVDAAYKPGMSPEEC
RSFTTNAIALAMNRDGSSGGVIHLVTITAAGVDYQVILGNELPKFYDE
3D structure
PDB8ysx Optimization of alpha-amido boronic acids via cryo-electron microscopy analysis: Discovery of a novel highly selective immunoproteasome subunit LMP7 ( beta 5i)/LMP2 ( beta 1i) dual inhibitor.
ChainF
Resolution2.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1L0D F T2 V20 S21 F31 K33 L45 S46 G47 A49 G128 S129 S168 S169 T1 V19 S20 F30 K32 L44 S45 G46 A48 G127 S128 S167 S168
Gene Ontology
Biological Process
GO:2000116 regulation of cysteine-type endopeptidase activity
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ysx, PDBe:8ysx, PDBj:8ysx
PDBsum8ysx
PubMed38906067
UniProtA0A8C0T7K4

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