Structure of PDB 8wqg Chain F

Receptor sequence
>8wqgF (length=85) Species: 9606 (Homo sapiens) [Search protein sequence]
RFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTV
AWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQK
3D structure
PDB8wqg cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 1)
ChainF
Resolution4.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
2.3.2.32: cullin-RING-type E3 NEDD8 transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN F C53 H82 C33 H62
BS02 ZN F C42 C45 H80 C83 C22 C25 H60 C63
BS03 ZN F H77 L96 D97 H57 L76 D77
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:8wqg, PDBe:8wqg, PDBj:8wqg
PDBsum8wqg
PubMed38670995
UniProtP62877|RBX1_HUMAN E3 ubiquitin-protein ligase RBX1 (Gene Name=RBX1)

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