Structure of PDB 8wqc Chain F

Receptor sequence
>8wqcF (length=85) Species: 9606 (Homo sapiens) [Search protein sequence]
RFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTV
AWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQK
3D structure
PDB8wqc cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CDK5R1
ChainF
Resolution3.54 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
2.3.2.32: cullin-RING-type E3 NEDD8 transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN F C53 C56 H82 C33 C36 H62
BS02 ZN F C42 C45 H80 C83 C22 C25 H60 C63
BS03 ZN F H77 C94 L96 D97 H57 C74 L76 D77
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:8wqc, PDBe:8wqc, PDBj:8wqc
PDBsum8wqc
PubMed38670995
UniProtP62877|RBX1_HUMAN E3 ubiquitin-protein ligase RBX1 (Gene Name=RBX1)

[Back to BioLiP]