Structure of PDB 8w8n Chain F

Receptor sequence
>8w8nF (length=346) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
SDPVRQYLHEIGQVPLLTLEEEVELARKVEEGMEAIKKLSEITGLDPDLI
REVVRAKILGSARVRHIPGLKETLDPKTVEEIDQKLKSLPKEHKRYLHIA
REGEAARQHLIEANLRLVVSIAKKYTGRGLSFLDLIQEGNQGLIRAVEKF
EYKRRFKFSTYATWWIRQAINRAIADQARTIRIPVHMVETINKLSRTARQ
LQQELGREPTYEEIAEAMGPGWDAKRVEETLKIAQEPVSLETPIGDEKDS
FYGDFIPDEHLPSPVDAATQSLLSEELEKALSKLSEREAMVLKLRKGLID
GREHTLEEVGAFFGVTRERIRQIENKALRKLKYHESRTRKLRDFLD
3D structure
PDB8w8n Nanopore tweezers show fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase.
ChainF
Resolution2.693 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna F E324 D326 S327 E247 D249 S250
BS02 dna F D79 V81 R82 L85 G89 L93 N191 R193 L194 S197 F209 F227 R231 F233 K234 S236 T237 Y238 W241 D2 V4 R5 L8 G12 L16 N114 R116 L117 S120 F132 F150 R154 F156 K157 S159 T160 Y161 W164
BS03 MG F A292 G296 A215 G219
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0016987 sigma factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0010468 regulation of gene expression
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w8n, PDBe:8w8n, PDBj:8w8n
PDBsum8w8n
PubMed38990947
UniProtQ5SKW1

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