Structure of PDB 8v4x Chain F

Receptor sequence
>8v4xF (length=358) Species: 9606 (Homo sapiens) [Search protein sequence]
QPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDL
TEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRS
ENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTPILDALKVTANIV
FGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMG
KCHLTKGKQALEIRSSLSEKRALTDPIQVRNLQWAKAHELPESMCLKFDC
GVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDA
NKGTPEETGSYLHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQ
EVNVGKPL
3D structure
PDB8v4x Inhibition of MALT1 and BCL2 induces synergistic anti-tumor activity in models of B cell lymphoma.
ChainF
Resolution2.486 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F K358 L359 D365 G414 H415 D462 C464 A498 F499 E500 I501 Q502 L541 K22 L23 D29 G78 H79 D126 C128 A161 F162 E163 I164 Q165 L204
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8v4x, PDBe:8v4x, PDBj:8v4x
PDBsum8v4x
PubMed38507740
UniProtQ9UDY8|MALT1_HUMAN Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Gene Name=MALT1)

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