Structure of PDB 8u5c Chain F

Receptor sequence

>8u5cF (length=575) Species: 9606 (Homo sapiens) [Search protein sequence]

PPSMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALP
ALLFKNMVVLNFSNVDWSFLYSILIAKASVFFIVCVLTLLVASPDSRFSK
AGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPI
GFIFCEIQKWKDTQNASQNKIKIVGLGLLRVLQNPIVFMVFIGIAFNFIL
DRKVPVYVENFLDGLGNSFSGSALFYLGLTMVGKIKRLKKSAFVVLILLI
TAKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFA
TQFNMEVEIITSGMVISTAVSAPIMYVSAWLLTFPTMDPKPLAYAIQNVS
FDISIVSLISLIWSLAILLLSKKYKQLPHMLTTNLLIAQSIVCAGMMIWN
FVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFLLKKRERVQIPVGI
IIISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSIL
IAGISLMCMNQQLTRHVLLCLLLIIGLFANLSSCLRWLFNQEPGRLYVEL
QFFCAVFNFGQGFISFGIFGLDKHL

3D structure

PDB

8u5c Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.

Chain

Resolution

2.68 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	Y01	F	F50 Y57 R61 M264 G266 I268 V348 F705 L713	F17 Y24 R28 M231 G233 I235 V315 F563 L571
BS02	Y01	F	R61 V353 R657	R28 V320 R515

External links

PDB	RCSB:8u5c, PDBe:8u5c, PDBj:8u5c
PDBsum	8u5c
PubMed
UniProt	Q7Z3F1\|LYCHS_HUMAN Lysosomal cholesterol signaling protein (Gene Name=GPR155)

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