Structure of PDB 8tqp Chain F

Receptor sequence
>8tqpF (length=210) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PIVQNLQGQMVHQCISPRTLNAWVKVVEEKAFSPEVIPMFSALSCGATPQ
DLNTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPVIAPGQMREPRGSDI
AGTTSTLQEQIGWMTHNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIR
QGPKEPFRDYVDRFYKTLRAEQASQEVKNETLLVQNANPDCKTILKALGA
TLEEMMTACQ
3D structure
PDB8tqp Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators.
ChainF
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K3L F K182 N183 K178 N179
BS02 K3L F N53 L56 N57 M66 Q67 L69 K70 I73 A105 G106 T107 Y130 N53 L56 N57 M66 Q67 L69 K70 I73 A101 G102 T103 Y126
Gene Ontology

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Biological Process
External links
PDB RCSB:8tqp, PDBe:8tqp, PDBj:8tqp
PDBsum8tqp
PubMed38054267
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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