Structure of PDB 8t75 Chain F

Receptor sequence
>8t75F (length=132) Species: 9606 (Homo sapiens) [Search protein sequence]
TIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHK
GKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQ
KFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWS
3D structure
PDB8t75 Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties
ChainF
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN F H139 C165 C168 C184 H83 C109 C112 C128
BS02 ZN F C152 C155 H173 C176 C96 C99 H117 C120
Gene Ontology
Biological Process
GO:0007165 signal transduction

View graph for
Biological Process
External links
PDB RCSB:8t75, PDBe:8t75, PDBj:8t75
PDBsum8t75
PubMed38354232
UniProtP04049|RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase (Gene Name=RAF1)

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