Structure of PDB 8swk Chain F

Receptor sequence
>8swkF (length=818) Species: 9606 (Homo sapiens) [Search protein sequence]
KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKESPIKME
LLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYL
FYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE
LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALE
KLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLF
TMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPLCA
HLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDC
EKFYSFIHMTFQEFFAAMYYLLELPSRDVTVLLENYGKFEKGYLIFVVRF
LFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLE
LFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESL
SLGFLHNLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQH
PGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL
LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENAL
GDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHL
YLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTS
SQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA
LETLQEEKPELTVVFEPS
3D structure
PDB8swk Cryo-EM structures of NLRP3 reveal its self-activation mechanism
ChainF
Resolution4.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7YN F A227 A228 I411 T439 F575 R578 Y632 A71 A72 I255 T283 F396 R399 Y453
BS02 ATP F I151 Y168 T169 G231 T233 I234 H260 E306 W416 H522 I19 Y36 T37 G75 T77 I78 H104 E150 W260 H358
External links
PDB RCSB:8swk, PDBe:8swk, PDBj:8swk
PDBsum8swk
PubMed
UniProtQ96P20|NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 (Gene Name=NLRP3)

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