Structure of PDB 8svm Chain F

Receptor sequence

>8svmF (length=512) Species: 5833 (Plasmodium falciparum)

SEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNP
GKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSV
AVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLF
RFFLETLFYEYMTDERFKSTEYIKHLGVYINNADTYKEEVEKARVYYFGT
YYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAY
LSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGS
MIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRP
GDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAM
LYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKY
ADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGF
GVRLLTEFVLND

3D structure

• PDB: 8svm Characterisation of a novel antimalarial agent targeting haemaglobin digestion that shows cross-species reactivity and excellent in vivo properties.
• Chain: F
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 3.4.11.1: leucyl aminopeptidase.
  3.4.13.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CO3	F	A460 G462 R463 L487	A369 G371 R372 L396
BS02	ZN	F	K374 D399 E461	K283 D308 E370
BS03	ZN	F	D379 D459 E461	D288 D368 E370
BS04	WRC	F	D379 M392 D459 E461 L487 T488 G489 L492 A577 F583	D288 M301 D368 E370 L396 T397 G398 L401 A486 F492

Gene Ontology

Molecular Function

• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0019538 protein metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8svm, PDBe:8svm, PDBj:8svm
• PDBsum: 8svm
• UniProt: Q8IL11|AMPL_PLAF7 Leucine aminopeptidase (Gene Name=LAP)