Structure of PDB 8sse Chain F

Receptor sequence
>8sseF (length=505) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
PLLERLKRRVVEGRKQGLEADLEEALKAGHKPLDLINGPLLAGMKEVGDL
FGAGKMQLPFVLQAAEVMKRAVAYLEPHMEKEGKGTLVLATVKGDVHDIG
KNLVDIILSNNGYRVVNLGIKVPIEEILKAVEAHKPHAVGMSGLLVKSTL
VMKENLEYMRDRGYTLPVILGGAALTRSYVEELRAIYPNVYYAEDAFEGL
RLMEELTGHAPPELTRARPVGEAPAVPRPPFFGVRVEEGLDLATIAHYVN
KLALYRGQWGYSRKGLSREAWQALVEREAEPVFQRLLKEAMAEGWLEPKV
LYGFFPVAREGEELLVFSPETGEVLERFRFPRQKGGGLSLVDYFRPRFAA
PLGDEADWMPKEAFRAGARDVLGVQLVTMGEAPSRKAQALFASGAYQDYL
FVHGFSVEMTEALAEYWHKRMRQMWGIAHQDATEIQKLFQQGYQGARYSF
GYPACPDLADQAKLDRLMGFHRVGVRLTENFQLEPEHATSALVVHHPEAR
YFSVD
3D structure
PDB8sse Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo
ChainF
Resolution3.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.13: methionine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B12 F H761 V768 M805 S806 L809 I833 G835 G836 A837 A860 V1087 S1129 F1130 G1131 Y1132 L1138 Q1162 L1163 E1166 A1168 S1170 H97 V104 M141 S142 L145 I169 G171 G172 A173 A196 V407 S449 F450 G451 Y452 L458 Q482 L483 E486 A488 S490
Gene Ontology
Molecular Function
GO:0008705 methionine synthase activity
GO:0031419 cobalamin binding
GO:0046872 metal ion binding
Biological Process
GO:0009086 methionine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8sse, PDBe:8sse, PDBj:8sse
PDBsum8sse
PubMed37821448
UniProtQ5SKM5

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