Structure of PDB 8rth Chain F

Receptor sequence
>8rthF (length=542) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
EVYLFHPAQYESAPATTRPNVLHYPAESTNPEFKANTERMKALTAELRRR
VQVIVDGDSEADKRARDRHISRGKLLVHQRIEKLVDPMSPFLELSQLAGG
DLYPGEACHRGGILTGIGVVHGMRVMIVANDATVKGGTYYPITVKKHLRA
QRIAEENRLPCIYLVDSGGANLGMQGDVFPDEQHFGRIFFNQANMSAKGI
AQIATVMGSCTAGGAYVPAMSDESIIVKGNGTIFLGGPPLVFAATGEEVT
PEELGGADVHCRASGVTDYFATDDLHALYLTRRIVANLNRNDCERPCRGR
EFTPPLYDPSEIGGFIPDMGADVVKGFDVRAVIARLVDGSEFDEFKKLYG
DTLVCGFARFEGMLVGIVANNGILYSESALKGAHFVELCSHRNIPLLFLQ
NITGFMVGKTYEEGGIAKNGAKLVTAVSTTHVPKITIIIGGSYGAGNYGM
CGRAFGPRFLFMWPNARISVMGGNQAATVLALTNSKLRENEVQDFKAKVR
SKYEYEGSCYYSTARLWDDGVIAPEDTRAVVVQALLSTLSAP
3D structure
PDB8rth The cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase provides mechanistic and dynamic insights into its enzymatic function
ChainF
Resolution2.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.4.1.4: methylcrotonoyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BTI F T462 G463 F464 N533 Q534 T403 G404 F405 N474 Q475
Gene Ontology
Molecular Function
GO:0004485 methylcrotonoyl-CoA carboxylase activity
GO:0016874 ligase activity
Biological Process
GO:0006552 L-leucine catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:1905202 methylcrotonoyl-CoA carboxylase complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8rth, PDBe:8rth, PDBj:8rth
PDBsum8rth
PubMed38593794
UniProtQ385A6

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