Structure of PDB 8r67 Chain F

Receptor sequence
>8r67F (length=334) Species: 9031 (Gallus gallus) [Search protein sequence]
MYTFVVRDENSSVYAEVSRLLLATGQWKRLRKDNPRFNLMLGERNRLPFG
RLGHEPGLVQLVNYYRGADKLCRKASLVKLIKTSPELSESCTWFPESYVI
YPTDEREVFLAAYNRRREGREGNVWIAKSILISSEASELLDFIDHVIQKY
LEKPLLLEPGHRKFDIRSWVLVDHLYNIYLYREGVLRTSSEPYNSANFQD
KTCHLTNHCIQKEYSKNYGRYEEGNEMFFEEFNQYLMDALNTTLENSILL
QIKHIIRSCLMCIEPAISTKHLHYQSFQLFGFDFMVDEELKVWLIEVNGA
PACAQKLYAELCQGIVDVAISSVFPLSIFIKLHH
3D structure
PDB8r67 Bridging the maytansine and vinca sites: cryptophycins target beta-tubulin's T5-loop.
ChainF
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.25: tubulin--tyrosine ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP F I148 K150 Q183 Y185 L186 K198 L240 T241 N242 D318 E331 N333 I126 K128 Q148 Y150 L151 K163 L205 T206 N207 D283 E296 N298
Gene Ontology
Molecular Function
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:8r67, PDBe:8r67, PDBj:8r67
PDBsum8r67
PubMed38735475
UniProtA0A8V0Z8P0

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