Structure of PDB 8qjr Chain F

Receptor sequence
>8qjrF (length=154) Species: 9606 (Homo sapiens) [Search protein sequence]
RPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRI
HSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLK
ERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQ
RMGD
3D structure
PDB8qjr PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
ChainF
Resolution3.17 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VLH F R69 W88 F91 Y98 P99 R107 I109 H110 S111 Y112 H115 W117 R10 W29 F32 Y39 P40 R48 I50 H51 S52 Y53 H56 W58
External links
PDB RCSB:8qjr, PDBe:8qjr, PDBj:8qjr
PDBsum8qjr
PubMed38180485
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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