Structure of PDB 8poh Chain F

Receptor sequence
>8pohF (length=623) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))) [Search protein sequence]
MDVNPTLLFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHKYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEIVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMDSMDKEEMEITTKKKQRLNKRSYLIRALT
LNTMTKDAERGKLKRRAIATPGMQIRGFVYFVEALARSICEKLEQSGLPV
GGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMIT
YITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQVPAEML
ANIDLKYFNKSTREKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSI
LNLGQKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLV
GINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADM
SVGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRA
FELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGR
LCNPMNPFVSDAVATTHSWIPKR
3D structure
PDB8poh The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
ChainF
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna F H32 R365 H32 R342
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8poh, PDBe:8poh, PDBj:8poh
PDBsum8poh
PubMed38316757
UniProtM9TLW3

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