Structure of PDB 8pn9 Chain F

Receptor sequence
>8pn9F (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
KISTEVGITNVDLSTVDKPKTTRVTYPAKAKGTFIAFALFFQLVDVNTGA
ELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFELDTSERKIEFDSASG
TYTLYLIIGDATLKNPILWNVADVVIKFPNLFTPKQEIQHLFREPEKRPP
TVVSNTFTALILSPLLLLFALWIRIGANVSNFTFAPSTIIFHLGHAAMLG
LMYVYWTQLNMFQTLKYLAILGSVTFLAGNRMLAQQAVKRT
3D structure
PDB8pn9 Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-kappa B.
ChainF
Resolution3.61 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN F Q527 H528 L529 Q139 H140 L141
BS02 EGY F Y593 M599 Y205 M211
Gene Ontology
Biological Process
GO:0006487 protein N-linked glycosylation
Cellular Component
GO:0008250 oligosaccharyltransferase complex
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:8pn9, PDBe:8pn9, PDBj:8pn9
PDBsum8pn9
PubMed38670073
UniProtP04844|RPN2_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Gene Name=RPN2)

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