Structure of PDB 8phi Chain F

Receptor sequence
>8phiF (length=453) Species: 11259 (Human respiratory syncytial virus A2) [Search protein sequence]
QNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCDAKVKL
IKQELDKYKNAVTELQLLMQSFLGFLLGVGSAIASGVAVCKVLHLEGEVN
KIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIS
NIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMP
ITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWK
LHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRV
FCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVS
CYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGK
SLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSA
IGG
3D structure
PDB8phi Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.
ChainF
Resolution2.289 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 336 F F137 F140 F488 F72 F75 F423
BS02 CA F Y457 Y458 Y392 Y393
Gene Ontology
Biological Process
GO:0019064 fusion of virus membrane with host plasma membrane

View graph for
Biological Process
External links
PDB RCSB:8phi, PDBe:8phi, PDBj:8phi
PDBsum8phi
PubMed38332002
UniProtP03420|FUS_HRSVA Fusion glycoprotein F0 (Gene Name=F)

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