Structure of PDB 8p2l Chain F

Receptor sequence
>8p2lF (length=496) Species: 6239,9606 [Search protein sequence]
GAGTEVQDALERALPELQQALSALKQAGGARAVGAGLAEVFQLVEEAWLL
PAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAE
NRDRVARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAA
GGLDAVLYWCRRTDPALLRHCALALGNCALHGGQAVQRRMVEKRAAEWLF
PLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALVEPLVASLDP
GRFARCLVDASDTSQGRGPDDLQRLVPLLDSNRLEAQCIGAFYLCAEAAI
KSLQGKTKVFSDIGAIQSLKRLVSYSTNGTKSALAKRALRLLGEEVPRPI
LPSVPSWKEAEVQTWLQQIGFSKYCESFREQQVDGDLLLRLTEEELQTDL
GMKSGITRKRFFRELTELKTFANYSTCDRSNLADWLGSLDPRFRQYTYGL
VSCGLDRSLLHRVSEQQLLEDCGIHLGVHRARILTAAREMLHSPLP
3D structure
PDB8p2l Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans.
ChainF
Resolution2.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
3.2.2.6: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD F W103 R110 E149 Q150 L152 V153 R157 H190 K193 R322 G323 D326 W48 R55 E94 Q95 L97 V98 R102 H135 K138 R267 G268 D271
Gene Ontology
Molecular Function
GO:0003953 NAD+ nucleosidase activity
GO:0035591 signaling adaptor activity
Biological Process
GO:0007165 signal transduction
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway
GO:0048678 response to axon injury

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Molecular Function
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Biological Process
External links
PDB RCSB:8p2l, PDBe:8p2l, PDBj:8p2l
PDBsum8p2l
PubMed37635352
UniProtQ6SZW1|SARM1_HUMAN NAD(+) hydrolase SARM1 (Gene Name=SARM1);
Q86DA5

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