Structure of PDB 8hj5 Chain F

Receptor sequence
>8hj5F (length=252) Species: 562,9606 [Search protein sequence]
QTLSLTVLTCIVSLVGLTGNAVVLWLLGCRMRRNAFSIYILNLAAADFLF
LSGRLIYSLLSFISPHTISKILYPVMMFSYFAGLSFLSAVSTERCLSVLW
PIWYRCHRPTHLSAVVCVLLWALSLLRSILEWMLCGFLFSGADSAWCQTS
DFITVAWLIFLCVVLCGSSLVLLIRILCGSRKIPLTRLYVTILLTVLVFL
LCGLPFGIQFFLFLWIHVDREVLFCHVHLVSIFLSALNSSANPIIYFFVG
SF
3D structure
PDB8hj5 Cryo-EM structure of Gq-coupled MRGPRX1 bound with Compound-16
ChainF
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U2U F K96 Y99 E157 W158 C173 D177 L240 K70 Y73 E131 W132 C147 D151 L214
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0006953 acute-phase response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
GO:1902349 response to chloroquine
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:8hj5, PDBe:8hj5, PDBj:8hj5
PDBsum8hj5
PubMed37347749
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
Q96LB2|MRGX1_HUMAN Mas-related G-protein coupled receptor member X1 (Gene Name=MRGPRX1)

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