Structure of PDB 8h6c Chain F

Receptor sequence
>8h6cF (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
GIIEFHVIGNSLKANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKH
KTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHL
KEYHIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGA
TLMECELNPRIPYT
3D structure
PDB8h6c Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications.
ChainF
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MLC F L531 V577 F578 C579 A580 V581 Q586 V587 G589 G591 T592 Y613 D615 Y617 A618 G620 Y621 F622 K624 L33 V79 F80 C81 A82 V83 Q88 V89 G91 G93 T94 Y115 D117 Y119 A120 G122 Y123 F124 K126
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

View graph for
Molecular Function
External links
PDB RCSB:8h6c, PDBe:8h6c, PDBj:8h6c
PDBsum8h6c
PubMed37040526
UniProtQ92830|KAT2A_HUMAN Histone acetyltransferase KAT2A (Gene Name=KAT2A)

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