Structure of PDB 8gvx Chain F

Receptor sequence
>8gvxF (length=305) Species: 9606 (Homo sapiens) [Search protein sequence]
EVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYKVVVYSNTIQSII
AIIRAMGRLKIDFGEAARADDARQLFVLELAGVIKRLWRDGGVQACFSRS
REYQLNDSASYYLNDLDRISQSNYIPTQQDVLRTRVKTTGIVETHFTFKD
LYFKMFDVGGLRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRM
HESMKLFDSICNNKWFTETSIILFLNKKDLFEEKIKRSPLTICYPEYTGS
NTYEEAAAYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVI
IKNNL
3D structure
PDB8gvx Molecular architecture of the G alpha i -bound TRPC5 ion channel.
ChainF
Resolution3.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP F E43 S44 G45 K46 S47 T48 L175 R176 T177 R178 T181 N269 K270 D272 C325 A326 T327 E11 S12 G13 K14 S15 T16 L132 R133 T134 R135 T138 N226 K227 D229 C282 A283 T284
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:8gvx, PDBe:8gvx, PDBj:8gvx
PDBsum8gvx
PubMed37137991
UniProtP08754|GNAI3_HUMAN Guanine nucleotide-binding protein G(i) subunit alpha-3 (Gene Name=GNAI3)

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