Structure of PDB 8guy Chain F

Receptor sequence
>8guyF (length=835) Species: 9606 (Homo sapiens) [Search protein sequence]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKD
DNEECGDICPCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCC
HSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSF
CQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPC
PKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANL
GLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIA
LKTNGDKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYK
EAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKP
WTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSS
SQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSCSC
PKTDSQILKELEESSFRKTFEDYLHNVVFVPRPHRPFEKVVNKESLVISG
LRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEI
FENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGC
RLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTD
3D structure
PDB8guy Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures
ChainF
Resolution4.18 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F D707 N711 P716 R717 D672 N676 P681 R682
BS02 peptide F D496 F497 R498 R539 N541 R717 D488 F489 R490 R531 N533 R682
BS03 peptide F N15 F39 K40 R65 N15 F39 K40 R65
External links
PDB RCSB:8guy, PDBe:8guy, PDBj:8guy
PDBsum8guy
PubMed36310231
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

[Back to BioLiP]