Structure of PDB 8foz Chain F

Receptor sequence

>8fozF (length=384) Species: 9606 (Homo sapiens) [Search protein sequence]

MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVD
LTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQ
ANEVRKVKKYERDYPLASKDAKKQLPCGAAIGTHEDDKYRLDLLAQAGVD
VVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVD
ALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQN
VGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDA
MDKHDKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF

3D structure

PDB

8foz Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	IMP	F	S68 M70 R322 G328 S329 I330 C331 D364 G387 S388 Y411 G413 M414 G415 Q441 G442	S68 M70 R203 G209 S210 I211 C212 D245 G268 S269 Y292 G294 M295 G296 Q311 G312
BS02	NAD	F	T252 H253 D274 S275 S276 F282 M325 C331 T333 M414	T133 H134 D155 S156 S157 F163 M206 C212 T214 M295

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0006183	GTP biosynthetic process
GO:0007623	circadian rhythm
GO:0046651	lymphocyte proliferation
GO:0071353	cellular response to interleukin-4
GO:0097294	'de novo' XMP biosynthetic process

	Cellular Component
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005778	peroxisomal membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0034774	secretory granule lumen
GO:0070062	extracellular exosome
GO:1904813	ficolin-1-rich granule lumen

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8foz, PDBe:8foz, PDBj:8foz
PDBsum	8foz
PubMed	37414152
UniProt	P12268\|IMDH2_HUMAN Inosine-5'-monophosphate dehydrogenase 2 (Gene Name=IMPDH2)

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