Structure of PDB 8fjz Chain F

Receptor sequence
>8fjzF (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
FNRDPRDHYDLLQRLGGGTYGEVFKARDKDLVALKMVKDVSTLQKEILIL
KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISY
VCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGAEL
ARRLEFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLF
DVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSAT
KMLSHQLVSQPGLNRGLILDLLDKLK
3D structure
PDB8fjz Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
ChainF
Resolution1.897 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y3I F V31 A44 K46 M91 F93 C94 D101 L144 D155 V23 A33 K35 M75 F77 C78 D85 L128 D139
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8fjz, PDBe:8fjz, PDBj:8fjz
PDBsum8fjz
PubMed36940470
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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