Structure of PDB 8ebx Chain F

Receptor sequence
>8ebxF (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
DELNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSN
KLAVIASHIQESRFLYDGKYELLTSANEVIVEEIKDLMTKSDIKGQHTET
LLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNVI
FAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVF
LPDQDQRSQLILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPI
CTTCETAF
3D structure
PDB8ebx Lesion recognition by XPC, TFIIH and XPA in DNA excision repair.
ChainF
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN F C268 C282 C285 C237 C251 C254
BS02 ZN F H258 C276 H227 C245
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006355 regulation of DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000438 core TFIIH complex portion of holo TFIIH complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005675 transcription factor TFIIH holo complex
GO:0097550 transcription preinitiation complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:8ebx, PDBe:8ebx, PDBj:8ebx
PDBsum8ebx
PubMed37076618
UniProtQ13889|TF2H3_HUMAN General transcription factor IIH subunit 3 (Gene Name=GTF2H3)

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