Structure of PDB 8e58 Chain F

Receptor sequence
>8e58F (length=973) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
FPSAVTIKSWVDKMQEDLVTLAKTASGVHQLVDIYEKYQDLYTVEPNNAR
QLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYN
AKDDLDPEKNDSEPGSQRIKPVFIDDANFRRQVSYQHAAVHIPTDIYEGS
TIVLNELNWTSALDDVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDN
SRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSV
SEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNIT
AKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKY
NKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEY
LDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENK
TNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPN
LQPKPIGVGIPTINLRKRRPNVQNPKSQEPVTLDFLDAELENDIKVEIRN
KMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTY
SFYYIKAKIEETITQARYSETLKPDNFEESGYTFLAPRDYCSDLKPSDNN
TEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWSKQKNI
KGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFT
APYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFT
KDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVN
ISVYAFNKSYDYQSVCEPGAASKQSCITEQTQYFFDNDSKSFSGVLDCGN
CSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPDPCDMVK
QPRYRKGPDVCFDNNVLEDYTDC
3D structure
PDB8e58 Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels.
ChainF
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA F S263 S265 T333 S235 S237 T305
External links
PDB RCSB:8e58, PDBe:8e58, PDBj:8e58
PDBsum8e58
PubMed36417914
UniProtP13806|CA2D1_RABIT Voltage-dependent calcium channel subunit alpha-2/delta-1 (Gene Name=CACNA2D1)

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