Structure of PDB 8cqk Chain F

Receptor sequence
>8cqkF (length=142) Species: 9606 (Homo sapiens) [Search protein sequence]
VLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHS
YRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKER
CLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQ
3D structure
PDB8cqk Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1 alpha Stabilizers.
ChainF
Resolution2.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VYQ F N67 W88 Y98 P99 I109 H110 S111 Y112 H115 W117 N6 W27 Y37 P38 I48 H49 S50 Y51 H54 W56
External links
PDB RCSB:8cqk, PDBe:8cqk, PDBj:8cqk
PDBsum8cqk
PubMed37708384
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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