Structure of PDB 8cbl Chain F

Receptor sequence
>8cblF (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
ATREFIEMWRLLGREVPEHITEEELKTLMECVSNTAKKKYLKYLYTKEKV
KKARQIKKEMKAAAREEAKNIKLLETTEEDKQKNFLFLRLWDRNMDIAMG
WKGAQAMQFGQPLVFDMAYENYMKRKELQNTVSQLLESEGWNRRNVDPFH
IYFCNLKIDGALHRELVKRYQEKWDKLLLTSTEKSHVDLFPKDSIIYLTA
DSPNVMTTFRHDKVYVIGSFVDKSMQPGTSLAKAKRLNLATECLPLDKYL
QWEIGNKNLTLDQMIRILLCLKNNGNWQEALQFVPKRKHTGFLE
3D structure
PDB8cbl Structural basis for human mitochondrial tRNA maturation.
ChainF
Resolution2.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.218: tRNA (adenine(9)-N(1))-methyltransferase.
2.1.1.221: tRNA (guanine(9)-N(1))-methyltransferase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0042802 identical protein binding
GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity
GO:0160106 tRNA (adenine(9)-N1)-methyltransferase activity
Biological Process
GO:0000964 mitochondrial RNA 5'-end processing
GO:0006397 mRNA processing
GO:0008033 tRNA processing
GO:0032259 methylation
GO:0070131 positive regulation of mitochondrial translation
GO:0070901 mitochondrial tRNA methylation
GO:0090646 mitochondrial tRNA processing
GO:0097745 mitochondrial tRNA 5'-end processing
GO:1990180 mitochondrial tRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0030678 mitochondrial ribonuclease P complex
GO:0042645 mitochondrial nucleoid
GO:0043527 tRNA methyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cbl, PDBe:8cbl, PDBj:8cbl
PDBsum8cbl
PubMed38824131
UniProtQ7L0Y3|TM10C_HUMAN tRNA methyltransferase 10 homolog C (Gene Name=TRMT10C)

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