Structure of PDB 8c2s Chain F

Receptor sequence
>8c2sF (length=428) Species: 10090 (Mus musculus) [Search protein sequence]
KTSFGSLKDEDRIFTNLYGRHDWRLKGALRRGDWYKTKEILLKGPDWILG
EMKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDR
EIMRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYE
AGLIGKNACGSDYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPP
FPADVGVFGCPTTVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLFNI
SGHVNHPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIP
KSVCETVLMDFDALVQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHES
CGQCTPCREGVDWMNKVMARFVKGDARPAEIDSLWEISKQIEGHTICALG
DGAAWPVQGLIRHFRPELEDRMQRFAQQ
3D structure
PDB8c2s Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1).
ChainF
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 F P203 C359 G360 Q361 C362 C365 T403 C405 L407 P195 C351 G352 Q353 C354 C357 T395 C397 L399
BS02 FMN F G67 G69 N96 D98 E99 Y184 G187 E188 E189 A223 N224 T227 A406 L407 G59 G61 N88 D90 E91 Y176 G179 E180 E181 A215 N216 T219 A398 L399
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0051287 NAD binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0009060 aerobic respiration
GO:0042775 mitochondrial ATP synthesis coupled electron transport
GO:0042776 proton motive force-driven mitochondrial ATP synthesis
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005829 cytosol
GO:0045271 respiratory chain complex I

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c2s, PDBe:8c2s, PDBj:8c2s
PDBsum8c2s
PubMed38177503
UniProtQ91YT0|NDUV1_MOUSE NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (Gene Name=Ndufv1)

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