Structure of PDB 8br4 Chain F

Receptor sequence
>8br4F (length=338) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
TVRVGINGFGRIGRNFYRALLAQQEQGTADVEVVAANDITDNSTLAHLLK
FDSILGRLPCDVGLEGDDTIVVGRAKIKALAVREGPAALPWGDLGVDVVV
ESTGLFTNAAKAKGHLDAGAKKVIISAPATDEDITIVLGVNDDKYDGSQN
IISNASCTTNCLAPLAKVLDDEFGIVKGLMTTIHAYTQDQNLQDGPHKDL
RRARAAALNIVPTSTGAAKAIGLVMPQLKGKLDGYALRVPIPTGSVTDLT
VDLSTRASVDEINAAFKAAAEGRLKGILKYYDAPIVSSDIVTDPHSSIFD
SGLTKVIDDQAKVVSWYDNEWGYSNRLVDLVTLVGKSL
3D structure
PDB8br4 Structure of GAPDH from Mycobacterium tuberculosis
ChainF
Resolution3.29 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD F G11 R12 I13 D39 I40 T104 G105 S127 C158 Q189 N320 Y324 G10 R11 I12 D38 I39 T103 G104 S126 C157 Q188 N319 Y323
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8br4, PDBe:8br4, PDBj:8br4
PDBsum8br4
PubMed
UniProtP9WN83|G3P_MYCTU Glyceraldehyde-3-phosphate dehydrogenase (Gene Name=gap)

[Back to BioLiP]