Structure of PDB 8ar8 Chain F

Receptor sequence
>8ar8F (length=483) Species: 9913 (Bos taurus) [Search protein sequence]
ADREDDPNFFKMVEGFFDRGASIVEDKLVEDQKRNRVRGILRIIKPCNHV
LSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALA
SLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFI
GPGVDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGI
HGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFAVQGFGNVGLH
SMRYLHRFGAKCVAVGESDGSIWNPDGIDPKELEDFKLQHGTILGFPKAK
IYEGSILEVDCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADK
IFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYH
LLMSVQESLERKFIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQI
MRTAMKYNLGLDLRTAAYVNAIEKVFRVYNEAG
3D structure
PDB8ar8 Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase.
ChainF
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.4.1.3: glutamate dehydrogenase [NAD(P)(+)].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP F I263 H269 K447 S453 R456 I195 H201 K379 S385 R388
BS02 ADP F H145 R146 A176 D179 V180 R519 K548 V552 H77 R78 A108 D111 V112 R445 K474 V478
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004352 glutamate dehydrogenase (NAD+) activity
GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
GO:0016491 oxidoreductase activity
GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
Biological Process
GO:0006520 amino acid metabolic process
GO:0006538 glutamate catabolic process
GO:0006541 glutamine metabolic process
GO:0032024 positive regulation of insulin secretion
GO:0072350 tricarboxylic acid metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ar8, PDBe:8ar8, PDBj:8ar8
PDBsum8ar8
PubMed36232607
UniProtA0A140T871

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