Structure of PDB 8a5k Chain F

Receptor sequence
>8a5kF (length=560) Species: 557722 (Pseudomonas aeruginosa LESB58) [Search protein sequence]
RERPATPLLDRASSPAELRRLGEADLETLADELRQYLLYTVGQTGGHFGA
GLGVVELTIALHYVFDTPDDRLVWDVGHQAYPHKILTERRELMGTLRQKN
GLAAFPRRAESEYDTFGVGHSSTSISAALGMAIAARLQGKERKSVAVIGD
GALTAGMAFEALNHASEVDADMLVILNDNDMSISHNVGGLSNYLAKFEEL
GWNYIGPIDGHDLPTLVATLRNMRDMKGPQFLHVVTKKGKGFAPAELDPI
GYHAITKLGPKYSSVFGQWLCDMAAQDARLLGITPAMKEGSDLVAFSERY
PERYFDVAIAEQHAVTLAAGMACEGMKPVVAIYSTFLQRAYDQLIHDVAV
QHLDVLFAIDRAGLVGEDGPTHAGSFDISYLRCIPGMLVMTPSDEDELRK
LLTTGYLFDGPAAVRYPRGSGPNHPIDPDLQPVEIGKGVVRRRGGRVALL
VFGVQLAEAMKVAESLDATVVDMRFVKPLDEALVRELAGSHELLVTIEEN
AVMGGAGSAVGEFLASEGLEVPLLQLGLPDYYVEHAKPSEMLAECGLDAA
GIEKAVRQRL
3D structure
PDB8a5k 1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding.
ChainF
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP F A87 H115 H157 S158 G186 D187 G188 A189 N216 M218 S219 I220 K286 I368 E370 F395 R398 A50 H78 H120 S121 G149 D150 G151 A152 N179 M181 S182 I183 K238 I309 E311 F336 R339
BS02 MG F D187 N216 M218 D150 N179 M181
BS03 CA F D486 D488 D427 D429
BS04 CA F G299 A302 G251 A254
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity
Biological Process
GO:0016114 terpenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8a5k, PDBe:8a5k, PDBj:8a5k
PDBsum8a5k
PubMed37567475
UniProtB7V7R4|DXS_PSEA8 1-deoxy-D-xylulose-5-phosphate synthase (Gene Name=dxs)

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