Structure of PDB 8a45 Chain F

Receptor sequence
>8a45F (length=573) Species: 557722 (Pseudomonas aeruginosa LESB58) [Search protein sequence]
MPKTLHEIPRERPATPLLDRASSPAELRRLGEADLETLADELRQYLLYTV
GQTGGHFGAGLGVVELTIALHYVFDTPDDRLVWDVGHQAYPHKILTERRE
LMGTLRQKNGLAAFPRRAESEYDTFGVGHSSTSISAALGMAIAARLQGKE
RKSVAVIGDGALTAGMAFEALNHASEVDADMLVILNDNDMSISHNVGGLS
NYLAKILFEELGWNYIGPIDGHDLPTLVATLRNMRDMKGPQFLHVVTKKG
KGFAPAELDPIGYHAITKLEGGPKYSSVFGQWLCDMAAQDARLLGITPAM
KEGSDLVAFSERYPERYFDVAIAEQHAVTLAAGMACEGMKPVVAIYSTFL
QRAYDQLIHDVAVQHLDVLFAIDRAGLVGEDGPTHAGSFDISYLRCIPGM
LVMTPSDEDELRKLLTTGYLFDGPAAVRYPRGSGPNHPIDPDLQPVEIGK
GVVRRRGGRVALLVFGVQLAEAMKVAESLDATVVDMRFVKPLDEALVREL
AGSHELLVTIEENAVMGGAGSAVGEFLASEGLEVPLLQLGLPDYYVEHAK
PSEMLAECGLDAAGIEKAVRQRL
3D structure
PDB8a45 Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa with 2-acetyl thiamine diphosphate
ChainF
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HTL F H115 S158 G186 D187 G188 A189 N216 M218 K286 I368 E370 F395 R398 H87 S130 G158 D159 G160 A161 N188 M190 K249 I322 E324 F349 R352
BS02 MG F D187 N216 M218 D159 N188 M190
BS03 CA F D486 D488 D440 D442
BS04 CA F G299 A302 G262 A265
BS05 CA F D413 G464 Y465 F467 D367 G418 Y419 F421
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity
Biological Process
GO:0016114 terpenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8a45, PDBe:8a45, PDBj:8a45
PDBsum8a45
PubMed37567475
UniProtB7V7R4|DXS_PSEA8 1-deoxy-D-xylulose-5-phosphate synthase (Gene Name=dxs)

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