Structure of PDB 7zcw Chain F

Receptor sequence
>7zcwF (length=426) Species: 9606 (Homo sapiens) [Search protein sequence]
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVY
YNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNN
WAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTL
LISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETY
CIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADL
RKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVK
TAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTG
EGMDEMEFTEAESNMNDLVSEYQQYQ
3D structure
PDB7zcw VASH1-SVBP and VASH2-SVBP generate different detyrosination profiles on microtubules.
ChainF
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G2P F Q11 C12 Q15 A97 N99 T143 G144 D177 Y222 N226 Q11 C12 Q15 A97 N99 T143 G144 D177 Y222 N226
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0001764 neuron migration
GO:0007017 microtubule-based process
GO:0007399 nervous system development
GO:0021987 cerebral cortex development
GO:0050804 modulation of chemical synaptic transmission
GO:1902669 positive regulation of axon guidance
GO:1990403 embryonic brain development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
GO:0045171 intercellular bridge
GO:0072686 mitotic spindle
GO:0098685 Schaffer collateral - CA1 synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zcw, PDBe:7zcw, PDBj:7zcw
PDBsum7zcw
PubMed36512346
UniProtQ9BVA1|TBB2B_HUMAN Tubulin beta-2B chain (Gene Name=TUBB2B)

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