Structure of PDB 7yq5 Chain F

Receptor sequence
>7yq5F (length=828) Species: 9606 (Homo sapiens) [Search protein sequence]
PGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPK
LIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKE
LGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNE
ECGDICPNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHS
ECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQ
DLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPK
VCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGL
IEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQ
LWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALK
TNGDKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEA
PYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWT
QYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQ
IILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPKTDSQI
LKELEESSFRKTFEDYLHNVVFVPRPHRPFEKVVNKESLVISGLRHFTGY
RIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVH
LMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSP
GNYSVRIRATSLAGNGSWTEPTYFYVTD
3D structure
PDB7yq5 Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures
ChainF
Resolution4.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F D707 H710 P716 R717 D665 H668 P674 R675
BS02 peptide F D496 F497 R498 R539 N541 F714 V715 R717 D486 F487 R488 R529 N531 F672 V673 R675
BS03 dna F R14 L37 F39 R65 Y67 F88 F89 F96 R11 L34 F36 R62 Y64 F85 F86 F93
External links
PDB RCSB:7yq5, PDBe:7yq5, PDBj:7yq5
PDBsum7yq5
PubMed36310231
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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