Structure of PDB 7yq4 Chain F

Receptor sequence
>7yq4F (length=614) Species: 9606 (Homo sapiens) [Search protein sequence]
PGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPK
LIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKE
LGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNE
ECGDICPNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHS
ECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQ
DLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPK
VCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGL
IEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQ
LWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALK
TNGDKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEA
PYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWT
QYAIFVKTLVTFSDERRTYGAKSDIIYVQTDPKTDSQILKELEESSFRKT
FEDYLHNVVFVPRP
3D structure
PDB7yq4 Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures
ChainF
Resolution3.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F D496 F497 R498 R539 N541 F714 V715 R717 D486 F487 R488 R529 N531 F610 V611 R613
BS02 peptide F D707 H710 P716 R717 D603 H606 P612 R613
BS03 dna F R14 L37 F39 R65 Y67 F88 F89 F96 R11 L34 F36 R62 Y64 F85 F86 F93
External links
PDB RCSB:7yq4, PDBe:7yq4, PDBj:7yq4
PDBsum7yq4
PubMed36310231
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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