Structure of PDB 7yhs Chain F

Receptor sequence

>7yhsF (length=334) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]

ILSTASVLAFERKLDPSDALMSAGAWAQRDASQEWPAVTVREKSVRGTIS
NRLKTKDRDPAKLDASIQSPNLQTVDVANLPSDADTLKVRFTLRVLGGAG
TPSACNDAAYRDKLLQTVATYVNEQGFAELARRYAHNLANARFLWRNRVG
AEAVEVRINHIRQGEVARTWRFDALAIGLRDFKADAELDALAELIASGLS
GSGHVLLEVVAFARIGDGQEVFPSQELILDKGDKKGQKSKTLYSVRDAAA
IHSQKIGNALRTIDTWYPDEDGLGPIAVEPYGSVTSQGKAYRQPKQKLDF
YTLLDNWVLRDEAPAVEQQHYVIANLIRGGVFGE

3D structure

PDB

7yhs Anti-CRISPR protein AcrIF4 inhibits the type I-F CRISPR-Cas surveillance complex by blocking nuclease recruitment and DNA cleavage.

Chain

Resolution

3.37 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	F	A32 F33 E34 R35 V68 R69 L95 W168 Q248 E249 L250 H275 Q277 K278 N281 R284 T308 S309 G352 V354	A9 F10 E11 R12 V45 R46 L72 W145 Q225 E226 L227 H252 Q254 K255 N258 R261 T285 S286 G329 V331
BS02	dna	F	V30 S92 P93 N94 L95 Q96 K258 G259	V7 S69 P70 N71 L72 Q73 K235 G236

External links

PDB	RCSB:7yhs, PDBe:7yhs, PDBj:7yhs
PDBsum	7yhs
PubMed	36209819

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