Structure of PDB 7y38 Chain F

Receptor sequence
>7y38F (length=468) Species: 371094 (Chikungunya virus strain S27-African prototype) [Search protein sequence]
DPVYVDIDADSAFLKALQRAYPMFEVEPRQVTPNDAANARAFSHLAIKLI
EQEIDPDSTILDIGSAPARRMMSDRKYHCVCPMRSAEDPERLANYARKLA
SAAGKVLDRNISGKIGDLQAVMAVPDTETPTFCLHTDVSCRQRADVAIYQ
DVYAVHAPTSLYHQAIKGVRLAYWVGFDTTPFMYNAMAGAYPSYSTNWAD
EQVLKAKNIGLCSTDLTEGRRGKLSIMRGKKLEPCDRVLFSVGSTLYPES
RKLLKSWHLPSVFHLKGKLSFTCRCDTVVSCEGYVVKRITMSPGLYGKTT
GYAVTHHADGFLMCKTTDTVDGERVSFSVCTYVPATICDQMTGILATEVT
PEDAQKLLVGLNQRIVVNGRTQRNTNTMKNYMIPVVAQAFSKWAKECRKD
MEDEKLLGVRERTAFKKQKTHTVYKRPDTQSIQKVQAEFDSFVVPSLWSS
GLSIPLRTRIKWLLSKVP
3D structure
PDB7y38 Molecular architecture of the Chikungunya virus replication complex.
ChainF
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN F H79 E129 C134 C141 H78 E128 C133 C140
BS02 GTP F R41 D152 Y154 Y248 E250 R40 D151 Y153 Y247 E249
BS03 ATP F S86 D138 P249 S85 D137 P248
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008174 mRNA methyltransferase activity
Biological Process
GO:0006396 RNA processing
GO:0016556 mRNA modification

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7y38, PDBe:7y38, PDBj:7y38
PDBsum7y38
PubMed36449616
UniProtQ8JUX6|POLN_CHIKS Polyprotein P1234

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