Structure of PDB 7x4y Chain F

Receptor sequence

>7x4yF (length=458) Species: 226186 (Bacteroides thetaiotaomicron VPI-5482)

EDLNFRKGDAKTDVFGSDRMLQPSPVERIPDGPTTPEVAYQMVKDETFAQ
TQPRLNLATFVTTYMDDYATKLMNEAININYIDETEYPRIAVMNGKCINI
VANLWNSPEKDTWKTGALAIGSSEACMLGGVAAWLRWRKKRQAQGKPFDK
PNFVISTGFQVVWEKFAQLWQIEMREVPLTLEKTTLDPEEALKMCDENTI
CVVPIQGVTWTGLNDDVEALDKALDAYNAKTGYDIPIHVDAASGGFILPF
LYPDTKWDFRLKWVLSISVSGHKFGLVYPGLGWVCWKGKEYLPEEMSFSV
NYLGANITQVGLNFSRPAAQILGQYYQFIRLGFQGYKEVQYNSLQIAKYI
HGEIAKMAPFVNYSENVVNPLFIWYLKPEYAKSAKWTLYDLQDKLSQHGW
MVPAYTLPSKLEDYVVMRVVVRQGFSRDMADMLLGDIKNAIAELEKLDFP
TPTRMAQE

3D structure

• PDB: 7x4y Coordinated regulation of Bacteroides thetaiotaomicron glutamate decarboxylase activity by multiple elements under different pH.
• Chain: F
• Resolution: 1.9 Å

Enzymatic activity

• Enzyme Commision number: 4.1.1.15: glutamate decarboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PLP	F	F315 S316	F314 S315
BS02	ABU	F	N81 D84 F315	N80 D83 F314
BS03	PLP	F	G122 S123 S124 Q161 V163 T210 D241 A243 H273 K274	G121 S122 S123 Q160 V162 T209 D240 A242 H272 K273
BS04	ABU	F	T60 F61 K274	T59 F60 K273

Gene Ontology

Molecular Function

• GO:0004351 glutamate decarboxylase activity
• GO:0016830 carbon-carbon lyase activity
• GO:0016831 carboxy-lyase activity
• GO:0030170 pyridoxal phosphate binding

Biological Process

• GO:0006536 glutamate metabolic process
• GO:0006538 glutamate catabolic process
• GO:0019752 carboxylic acid metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:7x4y, PDBe:7x4y, PDBj:7x4y
• PDBsum: 7x4y
• PubMed: 36358099
• UniProt: Q8A4M9