Structure of PDB 7wm4 Chain F

Receptor sequence
>7wm4F (length=668) Species: 10090 (Mus musculus) [Search protein sequence]
QCTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQ
LAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLT
ELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQEL
LLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFAL
LLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLKWTNL
TQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRY
LSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFT
GLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGT
FSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQLSTSSF
ALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLL
EGLENLEILDFQHNNLARLWNPGGPVNFLKGLSHLHILNLESNGLDEIPV
GVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDV
FGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQTHTNISELSTHYLCNT
PHHYYGFPLKLFDTSSCK
3D structure
PDB7wm4 TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction.
ChainF
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna F H40 K42 H61 N62 Q63 F85 N86 S87 E111 R545 K620 H13 K15 H34 N35 Q36 F58 N59 S60 E84 R518 K590
BS02 rna F R65 E111 S113 N518 H540 N542 G574 R38 E84 S86 N491 H513 N515 G544
External links
PDB RCSB:7wm4, PDBe:7wm4, PDBj:7wm4
PDBsum7wm4
PubMed36631495
UniProtQ99MB1|TLR3_MOUSE Toll-like receptor 3 (Gene Name=Tlr3)

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