Structure of PDB 7whs Chain F

Receptor sequence
>7whsF (length=366) Species: 5661 (Leishmania donovani) [Search protein sequence]
MRAVILVGGFGTRLRPLTLTTPKPLVPFCNKPMIIHQIEALKAVGVTEVI
LAVAYRPEAMKEQMDEWSRKLGVSFVFSVEEEPLGTAGPLALARDILMQD
DKPFFVLNSDVTCTFPMQELLDFHKAHGGEGTIMVSQVTQWEKYGVVVYS
PQNYQIERFVEKPSRFLGDRINAGIYIFNKSILDRIPPRRASIEKEIFPA
MAAEGQLYAFNLEGFWMDVGQPKDYILGMTKFIPSLVHGNRETEAVEHQR
GGRFTVIGASLIDPSAKIGDGAVIGPYASIGANCVIGESCRIDNAAILEN
SKVGKGTMVSRSIVGWNNRIGSWCHIKDISVLGDDVEVKDGVILIGTKVL
PNKDVGEHRFEPGIIM
3D structure
PDB7whs Structural insights into selective inhibition of leishmanial GDP-mannose pyrophosphorylase.
ChainF
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.13: mannose-1-phosphate guanylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP F L14 G16 G17 G19 R21 K31 A60 G93 N116 D118 L6 G8 G9 G11 R13 K23 A52 G85 N108 D110
BS02 MG F D118 D226 D110 D218
Gene Ontology
Molecular Function
GO:0004475 mannose-1-phosphate guanylyltransferase (GTP) activity
GO:0005525 GTP binding
GO:0016740 transferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0009058 biosynthetic process
GO:0009298 GDP-mannose biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7whs, PDBe:7whs, PDBj:7whs
PDBsum7whs
PubMed36038534
UniProtE9BG32

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