Structure of PDB 7w3i Chain F

Receptor sequence
>7w3iF (length=400) Species: 9606 (Homo sapiens) [Search protein sequence]
EQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIK
ENSEKIKVNKTLPYLVSNVIELLDVDPNKGKCAVIKTSTRQTYFLPVIGL
VDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIG
GLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARA
CAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELD
AIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILD
PALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTD
DFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
3D structure
PDB7w3i USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.
ChainF
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP F R344 R347 R305 R308
BS02 ATP F I188 P229 G230 T231 G232 K233 T234 L235 N333 I365 H369 G393 I149 P190 G191 T192 G193 K194 T195 L196 N294 I326 H330 G354
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
GO:0042802 identical protein binding
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043921 modulation by host of viral transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0000932 P-body
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex
GO:0034774 secretory granule lumen
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w3i, PDBe:7w3i, PDBj:7w3i
PDBsum7w3i
PubMed35477760
UniProtP17980|PRS6A_HUMAN 26S proteasome regulatory subunit 6A (Gene Name=PSMC3)

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